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Mexidol: instructions for use, contraindications and dosage

Mexidol is a medical drug that protects neurons and myocardial cells from the damaging effects of free radicals. The tool increases stress resistance, relieves intoxication (including alcohol) and reduces convulsive readiness.

Mexidol is a nootropic agent of a new generation, which has antihypoxic, antishock and antidepressant effects. The active ingredient (ethylmethylhydroxypyridine) prevents the formation of peroxide lipids and protects cells from aging.


Mexidol: from what helps?

Mexidol: from what helps?

The drug activates metabolic reactions, improves microcirculation, reduces blood viscosity and improves cerebral circulation. It protects the cell membranes of erythrocytes and platelets from destruction, reduces cholesterol levels.

Normalizes redox processes in the brain cells.

Mexidol relieves the symptoms of alcohol intoxication with withdrawal symptoms. Restores cognitive function, eliminates vegetative imbalance after prolonged hard drinking.

Enhances the action of other means: tranquilizers, neuroleptics and anticonvulsants.

Mexidol helps with depression, improves memory and increases learning ability.

Acceptance of mexidol in ischemic heart disease contributes to the preservation of the myocardium by strengthening the myocardiocyte membrane, as well as protecting the vascular wall from cholesterol deposition.

Contributes to the formation of collateral circulation in conditions of myocardial damage after a heart attack.

Mexidol: mechanism of action

The drug reduces the formation of peroxide substances that destroy cell membranes, which leads to increased oxygen delivery to the tissues and preservation of tissue structures.

Mexidol activates enzymes: superoxide dismutase, calcium independent phosphodiesterase, acetylcholinesterase.

It improves the transmission of nerve impulses in synapses and binding to ligands. Mexidol increases the formation of neurotransmitters, in particular dopamine.

The drug triggers glycolysis reactions and provides the Krebs cycle oxidative processes during tissue hypoxia, which supports the formation of ATP, creatine phosphate at the required level.

Mexidol: when used?

Mexidol: when used? The drug is used as an antioxidant in neurology, cardiology and psychiatry.

Indications for use Mexidol following:

  • Residual effects after strokes, as well as transient cerebral ischemia for the prevention of exacerbation;
  • Concussion of the brain, the effects of head injuries;
  • Acute and chronic encephalopathy;
  • Vegetative dysfunction;
  • Neurosis-like states;
  • Panic attack;
  • Cognitive impairment on the background of cerebrosclerosis;
  • Acute disorders of the coronary circulation, as an additional therapy;
  • In surgery after surgery, purulent inflammation of the peritoneum and pancreatitis;
  • Psychopathy, withdrawal syndrome;
  • Acute intoxication with psychotropic drugs;
  • Neurasthenic conditions after intense physical exertion;
  • For prophylaxis before extreme loads.

Contraindications Mexidol

  • Hepatic failure in the terminal stage;
  • Anuria;
  • Hypersensitivity to the active substance.

The drug is non-toxic. Does not affect coordination, blood pressure and respiration.

Side Effects of Mexidol

Possible side effects from the digestive organs: nausea, vomiting, diarrhea.

Possible allergic reaction by the type of urticaria, angioedema.

Mexidol: instructions for use

Mexidol: instructions for use

Tablet form

Mexidol tablets prescribed by 375-750 mg / day.

Reception scheme:

The first day is 1-2 tablets (125-250 mg).

Then the dose is increased to the most effective, but not more than 800 mg / day.

Treatment is prescribed for cardiac patients for 1.5-2 months. Preventive reception is carried out in the spring-summer offseason.

Symptoms of overdose are manifested by increased drowsiness.

Mexidol in ampoules

The drug is prescribed for intravenous jet, slow (5-7 min) administration, and drip - 60 drops / min. Before jet injection diluted in an isotonic solution.

Intramuscular administration is carried out deep in the tissue of the upper outer quadrant of the gluteus muscle.

The dosage regimen is prescribed individually: 1-2 ampoules 1-3 p / day. The maximum daily dose is 0.8 g.

  • For the treatment of dementia - injected in / muscular 0.1-0.3 g / day.
  • With alcohol withdrawal - intravenously - 0.5 g / day.
  • Neuroleptic poisoning - 0.3 g / day.
  • In surgical practice, for the treatment of peritonitis, pancreatitis - 0.2 g 3p / day.
  • In severe necrotic pancreatitis, 0.8 g twice a day for the first two days, then 0.5 2p / day drip.
  • For acute strokes and dyscirculatory encephalopathies - 500 g 4 p / day for two weeks.
  • The drug is discontinued gradually after achieving positive clinical and laboratory results.
  • For prophylactic purposes - 200 mg 2 p / day, the course - 14 days.
  • In stationary conditions, Mexidol is prescribed to children for the treatment of neuroinfection of 0.1 mg. intramuscularly.
  • 5% Mexidol solution is used for rinsing the mouth for stomatitis, gingivitis and purulent inflammation in the periodontal pocket. Apply 3 p / day.

Mexidol is broken down in the liver, excreted in the urine. Action time - 4 hours.

Interaction with other drugs

Meskidol potentiates the action of protusonitis, benzodiazepines, antidepressants. Reduces the toxicity of ethyl alcohols.

Mexidol indications during pregnancy and lactation

In connection with the lack of evidence of the safety of the drug for pregnant and lactating mothers, it is recommended to refrain from taking during the period of carrying and feeding the baby.

special instructions

Special instructions Mexidol Combined with pharmaceutical preparations that are used in therapeutic practice. In pediatrics, they are not used for special reasons, since there is no evidence of safety.

When you receive you can not drive a car and other vehicles that require quick response.

It is released in the pharmacy network by prescription.

Mexidol: release form

The active ingredient that provides the antioxidant activity of the drug is ethyl methyl hydroxypyridine succinate.

The release form is a solution for parenteral administration with a concentration of the active substance 50g / l and tablets 125 mg.

Form release: dark or light ampoules with a break point. Volume 2 ml of 5% solution. Ampoules are sold in contour plastic cells of 5 pcs.

Tablets - 10 tab. In a blister, and 90 pcs. - in plastic cans.

Storage conditions

With proper storage (in a cool, dark place) it is suitable for 3 years.


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