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Fluconazole: properties, instructions for use, how to drink for thrush

A fungus is a microorganism that can cause serious diseases. It can affect the skin (especially loves the feet and palms), nail plates, mucous membranes and even internal organs.

A fungal infection causes a lot of inconvenience, so you need to get rid of it and, preferably, do it at an early stage of the lesion. One of the effective drugs that helps to cope with an annoying disease is Fluconazole.


Pharmacological properties

Fluconazole is an antifungal agent. Its specific effect on the infection is manifested by the inhibition of the activity of enzymes that are important for fungi and depend on cytochrome P450.


Fluconazole photo

The drug also prevents the conversion of lanosterol to ergosterol. Due to the depressurization of the cell membrane, the growth and development of the cells that make up the fungus are disrupted. Therefore, the microorganism dies.

The drug selectively inhibits enzymes, negatively affecting cytochrome P450, and at the same time does not suppress biologically active substances of the human body at all. It also does not reduce the concentration of male sex hormones in the blood.

What helps Fluconazole?

The drug is indicated for the following diseases:

  • cryptococcosis (as well as cryptococcal meningitis) - diseases of the central nervous system or brain, caused by parasitic yeast-like microorganisms;
  • candidiasis of internal organs and systems, candida sepsis;
  • damage to the mucous membranes of the mouth and throat, esophagus and intestines;
  • genital candidiasis (damage to the vaginal walls and glans penis);
  • mycosis of the skin and nail plate;
  • bran versicolor;
  • endemic infiltrative mycoses, coccidioidomycosis and sporotrichosis.

Fluconazole is also used as a prophylaxis:

  • genital candidiasis, which is exacerbated more than 3-4 times a year;
  • fungal infections in patients who suffer from cancer and AIDS;
  • thrush, if there was sexual contact with a sick partner.

Instructions for use Fluconazole

Instructions for use Fluconazole

The drug is taken orally.

Instructions for use of Fluconazole: Adolescents and adults (weighing more than 45 kg) for the treatment of cryptococcal meningitis, as well as other cryptococcal infections, it is recommended to take Fluconazole according to a specific scheme: a single daily dose should be 400 mg (eight capsules of 50 mg), in the following days - 200 mg (four 50 mg capsules). The course of treatment depends on the severity of the disease and is set by the attending physician. On average, the duration of therapy is 6-8 weeks.

The treatment of generalized candidiasis follows a similar pattern. On the first day, the patient takes 400 mg, and the next 200 mg. If the course is severe and neglected, then treatment with a single “loading” dose of 400 mg ranges from 2 to 5 days (at the discretion of the physician). Treatment of bran-like lichen should be carried out in a similar pattern.

If skin and nail plate lesions are affected with mycosis, pulse therapy is recommended. According to the instructions for use, Fluconazole 150 mg should be taken every 7 days. The treatment of nail fungus lasts until a healthy translucent horn plate grows. On average - it is from 3 to 6 months, in severe cases - up to a year. The duration of the treatment of the fungus on the skin is much less and is approximately from 4 to 6 weeks.

Fluconazole is also effective for deep endemic mycoses. The treatment is very long and sometimes delayed for several years. Daily intake, depending on the complexity of the flow, ranges from 200 to 400 mg. The duration of treatment of histoplasmosis and sporotrichosis is recommended from several months to one and a half years, and coccidioidomycosis - from one to two years.

If the patient undergoes hemodialysis, then he is recommended 50 mg after each session.

How to drink fluconazole with thrush?

In order to effectively get rid of thrush (candidiasis), women and men are recommended to undergo treatment simultaneously. During the period of therapy is best to refrain from sexual contact. The treatment regimen for candidiasis of both partners is the same.

In the acute form of thrush, a single dose of Fluconazole 150 mg is recommended. Three days later, therapy should be fixed 50 mg of the drug.

The chronic form of the disease is much more difficult to treat. The treatment regimen is as follows: 150 mg of the drug be taken twice a day for three days. Then recommended treatment with a similar dosage in the first days of the menstrual cycle. The duration of therapy is from 1/2 to 1 year.

For the treatment of oral thrush, pharynx and esophagus more gentle therapy is used. Thus, the patient is recommended to take a daily dose of 50-100 mg for a week. With intestinal candidiasis, the scheme is slightly different: 50 mg 2 times a day. The course of treatment is also 5-7 days.

Before taking Fluconazole, you should consult with your doctor!

Contraindications Fluconazole

Fluconazole treatment is not recommended for the following diseases:

  • hypersensitivity to the drug and severe allergic reactions to it in the past;
  • concomitant use of Terfenadine and Astemisol and other drugs that affect electrical systole of the ventricles.

Children who are under 4 years old, the drug is strictly contraindicated!

Treatment should be carried out with extreme caution to those who suffer from a violation of the liver and kidneys. At the same time taking hepatotoxic drugs and drugs that affect the heart rate, you should consult with your doctor about the possible risks. If, during the treatment period, a rash of unknown origin has occurred on the skin, then it is necessary to temporarily discontinue therapy to avoid an allergic reaction.

Fluconazole during pregnancy and breastfeeding

Fluconazole during pregnancy The use of antifungal agent in the period of gestation is contraindicated, except in cases where the infection threatens the mother's life.

According to the instructions for use of Fluconazole, during the period of active therapy, the concentration of the basic substance in milk and plasma is the same, therefore, during lactation, treatment with an antifungal agent is prohibited.


Apply fluconazole in capsules or tablets should be according to the instructions. Otherwise, the patient may experience signs of intoxication: nausea, vomiting, diarrhea, and sometimes - hallucinations and other mental abnormalities.

At the first sign of poisoning, seek medical attention. Under the conditions of a hospital, gastric and intestinal lavage is performed, and in severe cases, hemodialysis.

special instructions

It is necessary to continue therapy according to the regimen prescribed by the doctor. The disappearance of visible signs of the disease in no case can not be regarded as a cure. If at this stage you stop therapy without authorization, then the fungal infection may return again.

If a fungal infection is suspected, you should seek help from a dermatologist (if skin is involved), a gynecologist (cheesy vaginal discharge) or a pediatrician (a child has white grains or a plaque in the mouth).

It is not recommended to start treatment with Fluconazole on your own!

This drug is usually recommended in a complex, that is, in parallel, should be carried out local effects on the infection with ointment or suppositories.

Timely diagnosis is the key to a speedy recovery! The fungus is not only unpleasant and ugly, it is also dangerous. Do not forget during treatment to follow the rules of personal hygiene, so as not to "reward" the household with an insidious infection.


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