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The rate of antibodies to thyroperoxidase is greatly increased - what does it mean?
Antibodies are protein-carbohydrate compounds produced by the immune system to recognize and eliminate pathogens. These substances are able to respond to the slightest changes and, with some pathologies, they begin to consider the substances and cells of the body to be foreign.
Conducting an analysis of the level of antibodies to microsomal thyroperoxidase helps to diagnose pathologies of the thyroid gland or other organs in the early stages of development.
- Антитела к тиреопероксидазе — что это такое? 1 Antibodies to thyroid peroxidase - what is it?
- Антитела к тиреопероксидазе сильно повышены — что это значит? 2 Antibodies to thyroperoxidase are greatly increased - what does this mean?
- Норма антител к ТПО (тиреопероксидазе), таблица 3 The norm of antibodies to TPO (thyroperoxidase), table
- Антитела к тиреопероксидазе при беременности повышенны 4 Antibodies to thyroid peroxidase during pregnancy are elevated
- Лечение при повышенных антителах к ТПО, препараты 5 Treatment with elevated antibodies to TPO, drugs
Antibodies to thyroid peroxidase - what is it?
The thyroid gland (abbreviated as thyroid gland) produces the vital hormones thyroxine and triiodothyronine, which regulate metabolic processes.
Thyroid peroxidase (or TPO) is the main enzyme in the synthesis of iodine-containing hormones. It is needed for the normal operation of the thyroid gland.
Antibodies to TPO are immunoglobulins, they act as a marker of autoimmune diseases of the thyroid gland.
They are also called microsomal, and they appear if the immune system takes thyroid cells as foreign. Getting with the flow of blood into the thyroid gland, these antibodies disrupt the formation of thyroid hormones.
Most often, antibodies to thyroid peroxidase are greatly increased in diseases of the thyroid gland, which for a long time have no pronounced symptoms. At the initial stages, apathy, deterioration of the condition of nails and hair, dry skin, nervousness are manifested, which many attribute to chronic fatigue or vitamin deficiency.
In the future hypotension appears, digestion, the work of the reproductive and musculoskeletal systems are disturbed. Lack of thyroid hormones provokes an increase in the thyroid gland, which presses on adjacent tissues and organs, causing hoarseness and soreness when swallowing. Immunity responds by producing antibodies to TPO.
Antibodies to thyroperoxidase are greatly increased - what does this mean?
If antibodies to thyroperoxidase are greatly increased, then this means that autoimmune aggression is directed to the thyroid tissue. This is observed pr:
In individuals who do not suffer from organ dysfunction, an increase in ATPPO (or ATPO) can be caused by other diseases that indirectly affect thyroid function:
- rheumatoid arthritis ;
- scleroderma ;
- autoimmune adrenal insufficiency;
- glomerulonephritis ;
- type I diabetes mellitus (insulin-dependent);
- systemic lupus erythematosus ;
- autoimmune gastritis:
- pernicious anemia.
A high level of antibodies to TPO can be both a cause and a consequence of thyroid pathologies. An increase in ATPPO can be provoked by some drugs - lithium or iodine preparations, Interferon, Amiodarone, glucocorticoids.
To detect antibodies to thyroperoxidase, venous blood serum is examined. If such antibodies were detected in a pregnant woman, then the analysis must also be carried out in a newborn.
A slight deviation of the ATTPO level from the norm can provoke:
- thyroid surgery, trauma;
- emotional overstrain;
- acute respiratory diseases;
- relapse of inflammatory pathologies;
- physiotherapy in the neck.
Regardless of the reasons for the increase in antibodies to thyroperoxidase, thyroid tissue as a result of an attack by immune cells is destroyed, which can trigger the development of:
- bazedovoy disease (toxic goiter);
- thyroiditis (inflammation of the thyroid gland);
- as a result, serious metabolic pathologies in the future.
The rate of antibodies to TPO (thyroid peroxidase), table
Table of the norm of antibodies to thyroperoxidase:
|Age||Norm AT to TPO (unit / l)|
|Up to 50 years||Up to 35|
|After 50 years||Up to 100|
With age, there is a tendency to increase antibodies to thyroid peroxidase in women, which is especially noticeable in the menopause and shortly before its onset. In addition to menopause, pregnancy and breastfeeding are critical.
Due to the particularities of the applied test systems, the standards of indicators and units for measuring the level of ATTPO may vary from laboratory to laboratory.
For example, in many clinics units / ml are used, in such cases the antibody level is considered to be the norm no more than 5.6.
Norm values are attached to the analysis results. However, self-decoding should not be done - only a specialist should diagnose the pathology and choose a treatment regimen.
- The ATPO test allows you to identify autoimmune pathologies at the earliest stages.
Antibodies to thyroid peroxidase during pregnancy are elevated
If a woman during the period of bearing a child's thyroid gland increases in size or an increase in the level of thyroid stimulating hormone (TSH) is diagnosed, then an analysis of ATPPO is considered mandatory. TSH is produced by the pituitary gland and affects the synthesis of iodine-containing hormones in the thyroid gland, so its increase may indicate hidden problems with the work of this organ.
Normally, in the early stages it should be low and not exceed 2 mU / l. If it is increased along with an increase in ATPPO, then this indicates the development of hypothyroidism.
An increase in antibodies to thyroid peroxidase during pregnancy can negatively affect not only the thyroid condition of a woman, but also the health of the unborn child. This is due to the fact that ATTPO freely overcome the placental barrier.
Treatment with elevated antibodies to TPO, drugs
High antibodies to thyroperoxidase primarily indicate hypothyroidism - a deficiency of thyroid hormones. In childhood, without treatment, this can lead to the development of cretinism, and in an adult, to myxedema.
Treatment of increasing ATPPO medication - hormones are prescribed by a doctor after a diagnosis. Of the drugs used Levothyroxine. The drug is contraindicated in acute heart attack, thyroid hyperfunction, adrenal insufficiency. Its analogues are L-thyroxine and Eutirox.
L-thyroxine is prescribed for pregnant women with TSH above 4 mU / L, even if antibodies to TPO are not elevated. Taking the drug helps maintain the proper functioning of the thyroid gland.
The effectiveness of therapy is indicated by a decrease in ATPO to insignificant or zero indicators. After treatment, it is important to regularly take tests for thyroid hormones and antibodies to TPO.